Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

D Swaroop; J Smith; J Van Zuykelom; A Noor; RA Wagner; T Vu; S Lee; AG Heriot; B Loveday; K Waldeck; PD Roselt; B Blyth; PS Donnelly; F Hollande

Journal article

Carbonic Anhydrase-IX Is a Specific and Sensitive Theragnostic Target for Imaging and Radioimmunotherapy in Metastatic Colorectal Cancer

D Swaroop, J Smith, J Van Zuykelom, A Noor, RA Wagner, T Vu, S Lee, AG Heriot, B Loveday, K Waldeck, PD Roselt, B Blyth, PS Donnelly, F Hollande

Gastro Hep Advances | Elsevier BV | Published : 2026

DOI: 10.1016/j.gastha.2025.100871

Abstract

Background and Aims: Over 40% of colorectal cancer (CRC) patients develop metastatic disease. Their survival outlook is very low, highlighting the urgent need to improve the detection and therapeutic management of metastatic colorectal cancer (mCRC), particularly when metastases are not surgically resectable. Our study aimed to characterize the preclinical utility of targeting carbonic anhydrase IX (CA-IX) for metastasis imaging and for therapeutic purposes in patients with CRC liver metastases. Methods: CA-IX expression was characterized in 46 liver metastasis samples using RNA sequencing and immunohistochemical staining. We labeled girentuximab, a clinical grade CA-IX antibody, with zircon..

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